Male erectile dysfunction could be a serious condition, that should not be treated haphazardly, but, luckily it has the possibility of a fast and valuable solution. sale cialis After isolating the toxin, the researchers radioactively labeled and injected a purified form of the toxin, Tx2-6, into rats that suffered from high blood pressure and severe erectile dysfunction. The investigators then measured the presence of the toxin in the animals' penises and used the toxin to contract and relax strips of penile tissue. Results showed improved levels of nitric oxide, which led to penile relaxation and erections. Most commonly, however, low testosterone is a result of aging. "[Male sex hormone] deficiency occurs with greater frequency in older-aged men," Cunningham says, but doctors don't know exactly why. "There are theories, but it's not well understood at this point." Exercise and eat a healthy diet to maintain good circulation. The authors declare no conflicting financial interests. Vacuum Devices Telephone number to call if severe drug side effects or complications develop: Inexpensive Need to take medication every day Most of the localization studies for PDE11 have been for PDE11A mRNA products. The data for protein are less certain as few highly specific antisera have been described. There also is likely to be substantial differences in expression between species. Nevertheless, it is clear that the PDE11A variants demonstrate differential tissue expression. In humans, PDE11A1 mRNA is most prominent in skeletal muscle and prostate (Fawcett et al., 2000; Yuasa et al., 2001a). PDE11A3 mRNA is found specifically in testis and PDE11A4 mRNA is highly expressed in prostate (Yuasa et al., 2000). PDE11A protein localization studies have been somewhat contradictory in their findings, probably because of differences in the specificity of the antibodies used. PDE11A1 protein was originally detected in prostate and skeletal muscle (Fawcett et al., 2000), although a later study did not detect PDE11A1 protein in any tissues (Loughney et al., 2005). In fact, only PDE11A4 protein has been verified and is found in prostate, pituitary, heart, and liver. Another study suggested that PDE11A is widely expressed, and immunohistochemistry using an antibody reported to recognize all PDE11A variants localized it to the epithelial, endothelial, and smooth muscle cells of many tissues, but at highest levels in the prostate, testis, kidney, adrenal gland, colon, and skin (D'Andrea et al., 2005). However, a separate study did not find any PDE11 protein expression in human testis (Loughney et al., 2005). As with many PDEs, it is still not clear if the same tissue, cellular, and subcellular localization is found among species. Future work will hopefully rectify the discrepancies regarding the tissue expression of PDE11A. Erection problems are very common. The Sexual Dysfunction Association estimates that 1 in 10 men in the UK have recurring problems with their erections at some point in their life. Intracavernosa injections Possible problems with prostheses include mechanical breakdown and infection. Mechanical problems have diminished in recent years because of technological advances. Erectile Dysfunction: Vascular Disease and ED This is similar to magnetic resonance imaging. Magnetic resonance angiography uses magnetic fields and radio waves to provide detailed images of the blood vessels. Doctors may inject a "contrast agent" into the patient's bloodstream that causes vascular tissues to stand out against other tissues. The contrast agent provides for enhanced information regarding blood supply and vascular anomalies. Aside from the IV used to introduce the contrast material into the bloodstream, magnetic resonance angiography is noninvasive and painless. Venous leak: If the veins in the penis cannot prevent blood from leaving the penis during an erection, an erection cannot be maintained. This is known as a venous leak, and can be a result of injury or disease. when L-NMMA was used to block NO production in the PVN, NMDA mediated penile erectile responses were blunted Reading books about sexuality.